Long-term atmospheric exposure to PCB153 and breast cancer risk in a case-control study nested in the French E3N cohort

BACKGROUND AND AIM: Although the genetic and hormonal risk factors of breast cancer are well identified, they cannot fully explain occurrence all cases. Epidemiological experimental studies have suggested that exposure to environmental pollutants, especially those with potential estrogenic properties, as polychlorinated biphenyls (PCBs) may a role in development. We aimed estimate association between cumulative atmospheric PCB153 risk. METHODS: conducted case-control study 5,222 cases matched controls nested within French E3N cohort from 1990 2011. Annual concentrations were simulated deterministic chemistry-transport model (CHIMERE) assigned women using their geocoded residential history. Their was calculated for each woman inclusion index date. Breast odds ratios (ORs) associated 95% confidence intervals (95% CI) estimated multivariate conditional logistic regression models. RESULTS:Overall, our results showed statistically significant linear increase related continuous variable (adjusted OR=1.19; CI: 1.08-1.31 an increment one standard deviation among (55 pg/m3)). Among who became postmenopausal during follow-up, remained OR=1.23; 1.09-1.39). In analyses by hormone receptors status, positive only ER-positive OR=1.18; 1.05-1.33). CONCLUSIONS:This is first impact on Our risk, which be limited cancer. Further needed confirm these findings. KEYWORDS: Polychlorinated biphenyls, Air pollution, cancer, Residential history, Nested